Hemp-Derived CBGA, CBDA, and the New Human Covid-19 (SARS-CoV-2, Alpha and Beta) Cannabinoid Research with CBGA (Cannabigerolic Acid) and CBDA (Cannabidiolic Acid).

Regurgitated, poorly, by Colin Valencia of OilWell CBD and Delta-8 THC of Houston, Texas.

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  • We are not doctors or medical professionals.
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  • Our mission for this product is, merely, to offer people a combination of Federall Legal hemp-derived non-THC Cannabinoids that they can enjoy in all 50 States.

Caused by the severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), the COVID-19 pandemic includes at least 272 million cases worldwide, 5.3 million deaths, and over 600 000 new cases daily as of December 2021.

Variants that, reportedly, have the capacity to escape humoral immunity and are associated with increased in infections & hospitalizations, and are gaining “competitive fitness over the original strains” are emerging, such as:

  • Variant B.1.1.7 (Alpha)
  • Variant B.1.351 (Beta)

Hemp is a strain of cannabis plant that has been cultivated to have a minimal concentration of THC, the main psychoactive ingredient in Cannabis, and is instead used in other commercial products such as textiles, cosmetics, or food. 

Oregon State University researchers have found that two isolated Cannabinoid compounds, CBGA (cannabigerolic acid) and CBDA (cannabidiolic acid), can block Covid-19 Alpha and Beta Strains from entering and infecting human cells.

What are CBDA and CBGA?

CBDA

CBDA, known as cannabidiolic acid, is secreted in the stems, leaves and flowers of a cannabis plant. When the plant undergoes activation (a process with heat), the acid is removed from the CBDA, activating CBD.

They have similar compounds, but CBDA is not as versatile. It’s usually extracted by “juicing” plant material, and can be added to foods, drinks, or used in tinctures, concentrated herbal extracts.

But basically, CBDA is the raw form of CBD. And it’s not as easy to find. But you can buy it. (It has not been studied as much as CBD)

CBGA

CBGA, known as cannabigerolic acid, is considered the “mother cannabinoid,” because without it, there is no CBD, CBDA or THC.

CBGA compounds are similar to other cannabinoids, but it hasn’t been studied nearly as much as the others. It’s non-intoxicating. Enzymes called synthases are responsible for converting the CBGA into molecules such as THCA, the raw, unactivated molecule that converts to THC after heat is applied.

Again, you can find this in oils and tinctures online, but it’s harder to find and at times, pretty expensive, because it’s harder to extract.

“These cannabinoid acids are abundant in hemp and in many hemp extracts,” said lead researcher Richard van Breemen at Oregon State’s Global Hemp Innovation Center in the College of Pharmacy and Linus Pauling Institute.

“They are not controlled substances like THC, the psychoactive ingredient in Cannabis such as hemp, and have a good safety profile in humans,” he said.

“And our research showed the hemp compounds were equally effective against variants of SARS-CoV-2, including variant B.1.1.7, which was first detected in the United Kingdom, and variant B.1.351, first detected in South Africa,” Breemen added.

Van Breemen noted that resistant variants could still emerge amid widespread use of cannabinoids but that the combination of vaccines and CBDA/CBGA treatment should make it more difficult for the bug to infect people.

They stated that CBGA and CBDA “have the potential to prevent as well as treat infection” by Covid-19, “as a complement to vaccines.”

“SARS-CoV-2 is an enveloped, nonsegmented, positive sense RNA virus that is characterized by crown-like spikes on the outer surface.”  Important to this interaction is that the spike proteins’ binding to the human cell surface for infection is necessary.  Cell-entry inhibitors, that would block this activity, would, then, prevent SARS-CoV-2 from spreading/infecting other cells, even during infection by immobilizing the binding spike activity.  Important to note is that the host cells, most receptive to this activity, are abundant in the lungs, arteries, heart, kidney, and intestines.

From the MagMASS ranking of Hemp Cannabinoids for Binding to the SARS-CoV-2 Spike Protein, the following are the top-3:

  1. cannabigerolic acid (CBGA)
  2. tetrahydrocannabinolic acid (THCA-A)
  3. cannabidiolic acid (CBDA)

There is a host of exciting new research on how Cannabinoids are being studied and reported!  We sourced most of the information, above, from the following sources: