Ultimate Guide to CBG
Most people have heard of tetrahydrocannabinol (THC) and cannabidiol (CBD) and their effects, but there are plenty more cannabinoids found in cannabis. Cannabigerol (CBG), which isn’t present in large quantities, may be beneficial for a number of conditions.
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What Is CBG?
Cannabigerol is a cannabinoid obtained from the cannabis plant and often referred to as the “mother of all cannabinoids.” This is due to the fact that all other cannabinoids are derived from cannabigerolic acid (CBGA), an acidic form of CBG.
CBG is found in smaller quantities than other cannabinoids, at roughly 1 percent. This is compared to roughly 20 to 25 percent CBD and 25 to 30 percent THC found in most plants. Because of this, consumer products containing CBG are rare and more expensive than other cannabinoids.
How Does CBG Work?
CBG is derived from young cannabis plants because they have higher concentrations of CBG than mature plants. Both THC and CBD begin as CBGA, an acidic form of CBG, which is why younger plants have higher concentrations. As the plant develops, CBG is converted into CBD and THC.
Certain strains of cannabis have higher CBG content than other strains, due to specific cultivation. Growers are able to cross-breed and genetically manipulate the plants to produce higher concentrations of CBG.
In the body, CBG is processed by the endocannabinoid system. This is a complex cell-signaling system that was first evaluated for its connection to THC. Continued research is needed, but researchers do know that the endocannabinoid system has numerous effects on the body, including sleep cycles, memory, mood, appetite, and more.
The endocannabinoid system is found in everyone. Cannabis isn’t part of it – the compounds just interact with it to produce similar effects as what the body does naturally.
The three components of the endocannabinoid system include endocannabinoids, receptors, and enzymes. Endocannabinoids are similar to the cannabinoids found in cannabis, but they’re produced independently. The two primary endocannabinoids identified by researchers are 2-arachidonoylglycerol (2-AG) and anandamide.
The two primary endocannabinoid receptors are:
- Cannabinoid receptor type 1 (CB1), which is found in the central nervous system
- Cannabinoid receptor type 2, which is found in the peripheral nervous system and immune system
Endocannabinoids and cannabinoids can act on these receptors to illicit different effects on the body.
The two primary enzymes in the endocannabinoid system are monoacylglycerol acid lipase, which breaks down 2-AG, and fatty acid amide hydrolase, which breaks down anandamide.
The endocannabinoid system regulates numerous processes in the body, including inflammatory response, stress response, memory, sleep cycles, heart function, motor control, pain reception, metabolism, reproduction, and skin and nervous systems.
This is the primary function of how cannabinoids can produce therapeutic effects. because the endocannabinoid system controls so many functions, different cannabinoids act on different endocannabinoids and can produce positive effects.
CBG works by binding to the two main endocannabinoid receptors and strengthens the function of anandamide, which enhances motivation and pleasure, alleviates pain, and regulates appetite. CBG has no THC and no psychoactive effects, so it doesn’t cause a euphoria or “high” feeling.
CBG Therapeutic Uses
CBG has many possible therapeutic effects, most notably with pain relief. Studies are limited in the effects of CBG for different health conditions, but it shows promise in animal studies.
Inflammatory Bowel Disease (IBD)
Inflammatory bowel disease is a condition that causes chronic inflammation in the bowel. It has no cure and effects millions of people all over the world.
In an experimental study on animals, CBG was shown to have beneficial effects for people with inflammatory bowel disease. For the study, researchers induced effects similar to inflammatory bowel disease in mice and then gave them CBG. It was found to reduce the inflammation and the production of nitric oxide, which is a mediator of intestinal inflammation.
Huntington’s disease is a condition that causes degeneration of the nerve cells in the brain. In a 2015 study, researchers examined the neuroprotective properties of CBG and other cannabinoids in mice with similar effects as Huntington’s disease. The results showed that CBG has neuroprotective properties and protects the brain cells from damage. It also improves movement issues, which is a common symptom of Huntington’s disease.
In early studies of CBG in rats with colon cancer, CBG showed promise in blocking the receptors that promote cancer cell growth and inhibiting the growth of those cancer cells. The results suggest that CBG could be part of the treatment, cure, and prevention of colon cancer.
Glaucoma is a group of eye conditions that damage the optic nerve, which is necessary for healthy vision. The damage is caused by abnormally high pressure in the eye, and eventually leads to blindness.
In animal studies, CBG was shown to have therapeutic potential for treating glaucoma. Researchers gave CBG to cats with glaucoma and saw a reduction in eye pressure, as well as an increase in aqueous humor outflow. This is a fluid that’s produced by the eye and helps to maintain eye pressure.
CBG is one of the cannabinoids that has antibacterial properties. Its properties are particularly notable with methicillin-resistant strains of Staphylococcus aureus (MRSA), a bacterium that is drug-resistant and can be deadly.
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Is CBG Legal?
Like CBD, CBG is legal to purchase, use, and produce under federal law as outlined in the Agriculture Improvement Act (2018 Farm Bill). All hemp-derived cannabinoids are legal under this bill, provided they’re sourced from hemp plants with no more than 0.3 percent THC.
It’s important to note, however, that while legal, CBG is largely unregulated. It’s vital to source products responsibly and do your research to ensure you’re getting a high-quality product that’s tested for potency.
At OilWell CBD, we test all of our products to ensure they’re safe and high-quality. We thrive on trust and transparency, and our CBG products are manufactured in small batches to ensure exceptional finished products.
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CBG is most commonly produced as an oil, though it’s somewhat rare and may be expensive. You can also get some of the benefits of CBG from broad-spectrum CBD oils, which contain all the cannabinoids found in the plant – minus the THC.
You may also find CBG in tinctures, capsules, gum, and in whole-plant flower.
When cannabinoids are used together, they can enhance each other’s efficacy. This is known as the “entourage effect.” Multiple cannabinoids can produce positive effects on a whole that are greater than their individual effects. in addition, the entourage effect leads cannabis compounds other than THC to act synergistically to modulate the overall psychoactive effects of any THC present.
The low concentration of CBG makes it rare and more difficult to produce than other cannabinoids. In addition, because it shares many similarities to CBD, many manufacturers choose to focus on the more abundant of the two.
When CBG is produced and sold as products, they tend to be more expensive than other cannabinoids. Still, it has a variety of promising therapeutic uses and more research into its efficacy will likely lead more manufacturers to find innovative ways to produce more of it.
In addition, CBG isn’t regulated by the Food and Drug Administration (FDA), so you may have to do more legwork to ensure you’re getting a quality product. Look for products that are tested by an independent lab and check out the lab report.
What’s the Differences Between CBG and CBD?
CBG may be compared – or even confused with – CBD because they’re both cannabinoids and act on the endocannabinoid system. Both CBG and CBD are non-psychoactive as well, which means they don’t produce the euphoric effects like THC.
One key difference, however, is the quantity of each cannabinoid found in cannabis plants. Most plants contain about 20 or 25 percent CBD, compared to 1 percent of CBG. In addition, CBG binds directly to the CB1 and CB2 receptors, making it more efficient at delivering therapeutic benefits.
The Future of CBG
Though early animal studies show promise for the therapeutic effects of CBG, more research is needed to determine the full range of its benefits. Currently, most research into cannabinoids focused on the potential of THC and CBD, but less so for the other cannabinoids.
Now that we have a deeper understanding of what THC and CBD can do, more research is conducted on the minor cannabinoids. Fortunately, early animal studies have shown good results for conditions like inflammatory bowel disease, glaucoma, cancer, and Huntington’s disease. As more studies are conducted, we may discover CBG as a viable treatment option for a wide range of other health conditions.
CBG Products at OilWell Cannabis
CBG is one of the rarest cannabinoids. It’s present in only small quantities in cannabis, as it develops into THC and CBD as the plant matures. Because of its rarity, it hasn’t been as well researched as other cannabinoids, but it’s showing early promise as a solution for a variety of ailments. The key to CBG may be its effects on the main endocannabinoid receptors, which have benefits for pleasure, relieving pain, and regulating appetite.
if you’re looking for CBG products, OilWell Cannabis has you covered. We offer a range of hemp-derived, farm-bill-compliant cannabinoids in a variety of products, including CBG. Contact us today to learn more!